Fig 6. Effects of LA, tenofovir and acyclovir on the viral titers in mice inoculated with HSV-2 G.

Groups of five female nu-nu mice were inoculated with HSV-2 on the lumbosacral area. Each group was treated topically two times a day for 5 consecutive days, starting 1 day prior to infection. The placebo cohort received a similar treatment with the test formulation without compound. On day 7 post-infection, swab samples were taken from animals that presented clear advanced lesions or small early lesions. The acyclovir group did not develop any lesions. Mean PFU/ml-values are indicated for each group. Statistical significance compared to placebo: *p<0.05, according to Mann-Whitney U test.