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. 2015 Jun 18;2015:203978. doi: 10.1155/2015/203978

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Copyright © 2015 Yang Xu et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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WM130 inhibits DMN-induced rat liver fibrosis. The model of liver fibrosis was induced by intraperitoneal injection with 1% DMN. Then rats were treated with M19 or WM130 by gavage. (a) The contents of the collagen fiber in liver tissue of DMN-induced rat were detected by Van Gieson's staining. The immunohistochemical staining was used to observe α-SMA, TGF-β1, p-AKT, and p-ERK positive areas in liver tissues of DMN-injured rats (at 200x magnification). (b) Sera were prepared from rat blood and used to determine the contents of ALT, AST, and Collagen I. ^∗∗ p < 0.01, ^∗∗∗ p < 0.001 versus normal Control; ^# p < 0.05, ^### p < 0.001 versus model Control.