Table 1.

Toxicity testing of the Maximum Extract 1 (Me-1) formulation on animals. The purified Me-1 was formulated to be included in the animal feed and submitted to a month-long acute toxicity studies on rats (about 300 g females). The animals were divided into four groups of four animals/cage. The rats in the first cage received no drug in their feed (placebo). Rats in the second cage were given a dose of Me-1 five times (× 5) the equivalent of the human dose (200 mg for a 70 kg person). Rats in the remaining two cages received 15 times (× 15) and 50 times (× 50) the equivalent of the human dose, respectively. All the animals were fed for 28 days with Me-1 product under identical conditions as the placebo group. At the end of the study, the animals were sacrificed and all blood parameters, liver enzymes, and histology of the major organs were analyzed by state-of-the-art methods. There was no statistically significant difference between the drug-treated groups and the placebo, neither was any significant difference found among the drug-treated groups. Me-1 was then formulated into blue capsules using a proprietary pharmaceutical method of capsule formulation.

Drug	Dose (in feed daily for 1 mo)	Toxicity (compared to placebo)
Placebo (No Me-1)	0 mg
Me-1 (× 5)	4.3 mg	No significant difference
Me-1 (× 15)	12.9 mg	No significant difference
Me-1 (× 50)	42.9	No significant difference