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. 2015 Jun 23;6(2):417–435. doi: 10.3390/genes6020417

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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Sequence of regenerative events and HH signaling. Longitudinal section of an unamputated and regenerating fin ray showing the basal layer (blue) and outer epidermis (yellow). Epidermal cells cover the wound and mesenchymal cells from the stump proliferate and migrate distally to form the blastema. HH signaling is induced in the lateral basal epidermal layer and a signaling center (green) in the apical region (yellow) that includes: FGF, WNT and BMP signaling leads to the induction of cellular proliferation (blue) and regeneration. Note the key is in the upper panel.