Table 1.
Summary of the anti-viral activity of the different APOBEC3 isoforms. * It has been recently shown that A3A can also edit RNA transcripts [79].
| Sub-cellular localization | Substrate edited | Retro viruses | Retro elements | Hepadna viruses | Herpes viruses | ||||
|---|---|---|---|---|---|---|---|---|---|
| HIV-1 | HTLV-1 | HERVs | SFV | ||||||
| A3A | cell wide | single stranded DNA, RNA * | + | + | + | ||||
| A3B | nuclear | single stranded DNA | + | ||||||
| A3C | cell wide | single stranded DNA | + | + | + | ||||
| A3DE | cytoplasmic | single stranded DNA | + | ||||||
| A3F | cytoplasmic | single stranded DNA | + | + | + | ||||
| A3G | cytoplasmic | single stranded DNA | + | + | + | + | + | ||
| A3H | cell wide | single stranded DNA | + | + | + | ||||