Table 1.

A selection of studies which document mutations in RNA viruses conferring resistance to siRNA.

Virus	siRNA target(s)	References
HIV	nef	[75,77,85]
	tat	[74]
	int	[76]
	att	[76]
	Multiple siRNA, mutations outside targeted sequence	[79,81]
Poliovirus	Multiple siRNAs	[69]
Hepatitis C	Multiple siRNA	[71]
JEV	Multiple siRNAs	[70,76]
FMDV	siRNA-resistant, no mutations in targeted sequence	[78]
Turnip Mosaic Virus	HC-Pro	[72]
PPRV	Nucleoprotein	[73]