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. 2015 Jul 2;9:152. doi: 10.3389/fnbeh.2015.00152

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Copyright © 2015 Gompf, Budygin, Fuller and Bass.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dual LC injection of TH-Cre-AAV and hM3Dq-AAV. (A) hM3Dq expression is limited to LC neurons. (B–D) Following CNO injections, c-Fos expression markedly increased in the LC (B) as well as the entire neocortex, including the ACC (C), which was not evident in LC or cortex of animals lacking hM3Dq receptors (D). (E) CNO induced wakefulness for most of the 6 h period following injection (blue line) compared to the normal amount of wakefulness observed following saline injection (red line). (F) Power spectral analysis revealed normal wake EEG signatures following CNO injection compared to saline (blue and red lines, respectively).