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RES suppresses the activity and expression of MMP-2 in GICs. (A) GICs (412) were treated with DMSO (vehicle) and 5 μM, 10 μM, and 20 μM RES for 48 h, respectively. The activity of MMP-2 was assessed using the concentrated conditioned medium (CM) by gelatin zymography; (B) Cell lysates were subjected to western blotting with anti-MMP-2 antibody to evaluate the protein expression of MMP-2. β-actin was used as a loading control. * p < 0.05, ** p < 0.01, vs. Vehicle.
