Table 3.

The effects of chronic dietary nitrate supplementation on tissue levels of nitrate/nitrite and therapeutic efficacy for experimental animal models.

Animal Model	Dietary Nitrate	Tissues	Effects of Dietary Nitrate	References
Uninephrectomized hypertension rat with high-salt diet.	Diets with 0.1 mM and 1 mM nitrate/kg/day for 8–11 weeks.	Kidney Heart Liver	Increase in plasma and tissue levels of nitrate and tissue levels of nitrosylation products. Reduction of oxidative stress and attenuation of renal injury, hypertension, cardiac hypertrophy and fibrosis.	[37]
C57BLK6 male mice with hypoxia-induced pulmonary hypertension.	0.6 mM, 15 mM, and 45 mM nitrate/L in drinking water for 3 weeks.	Lung	Increase in plasma and lung levels of nitrite and cGMP. Reduction of right ventricular pressure and hypertrophy, and pulmonary vascular remodeling.	[38]
Male Wistar rat with hypoxic heart damage.	0.7 mM/L nitrate in drinking water for 2 weeks.	Heart	Increase in plasma levels of nitrate and tissue levels of nitrite. Alleviation of metabolic abnormalities in the hypoxic heart. Improvement of myocardial energetics.	[39]