Table 6. Clinical background of patients with long-QT interval and RYR2 mutation.

cDNA level change	Protein level change	age	sex	Affected family members	QTc	event
c.497C>G	p.S166C	11	F	none	416	Syncope during swim, novel
c.1259G>A	p.R420Q	14	M	none	412	Syncope during swim (12 y), SD (17 y)
c.1298T>C	p.L433P	18	F	none	452	VF during exercise (17 y)
c.5278C>T	p.R1760W	16	M	none	425	Syncope during swim, novel
c.8470C>T	p.R2824W	7	M	none	439	Asympt, novel
c.11017C>T	p.R3673W	16	M	none	469	Heart failure, novel
c.12272C>T	p.A4091V	16	M	none	443	CA during exercise
c.12438G>C	p.E4146D	2	F	none	401	VF, novel
c.13780A>C	p.K4594Q	12	F	none	496	Syncope during swim (10 y), novel