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. Author manuscript; available in PMC: 2015 Jul 2.
Published in final edited form as: Nat Struct Mol Biol. 2014 Nov 24;21(12):1100–1105. doi: 10.1038/nsmb.2919

Figure 2.

Figure 2

An evolutionarily conserved local dip in translational efficiency characterizes the SRP-dependent translocation of the essential N-oligosaccharyl transferase (OST). (a) Four of eight OST subunits, namely OST1, OST3, SWP1 and WBP1, have a distinct topology of an SS followed by a long lumenal domain. (b) Median translational efficiency (TE) profile of the OST subunits OST1, OST3, SWP1 and WBP1, showing a distinct region of low TE (gray bar) ~40 codons downstream of the start of the hydrophobic region of the SS (yellow bar). (c) Evolutionary conservation of the region of low TE (gray bars) ~40 codons downstream of the start of the hydrophobic region of the SS (yellow bars) in OST subunits across closely related yeast species. TE profiles show predicted relative translation speeds and are in arbitrary units (AU).