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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Kidney Int. 2015 Feb 25;88(1):52–60. doi: 10.1038/ki.2015.29

Figure 5. Total (T-) SYK expression in anti-glomerular basement membrane (anti-GBM) disease and ANCA-associated glomerulonephritis (AAGN).

Figure 5

(A & B) Sequential sections showing positive and negative control (NC) staining for T-SYK in a crescentic glomerulus in anti-GBM disease. (C) Glomerular T-SYK expression correlates strongly with presenting serum creatinine in anti-GBM disease (n=15 cases; Spearman r = 0.78, p=0.0006). (D) T-SYK staining in AAGN localises to areas of crescent formation. (E) Minimal glomerular staining for T-SYK in a scarred glomerulus in sclerotic-class AAGN. (F) Correlation of glomerular T-SYK staining with histologic class of AAGN, with highest levels seen in crescentic class disease. All sections are immunoperoxidase stains with haematoxylin counterstain, x200-400 magnification. Negative control (NC) stains were performed by pre-incubating the primary antibody with the relevant immunising peptide. GCS, glomerular cross section. ** p<0.01, *** p<0.001.