Table 1. Baseline Comparability Across Randomization Arms (Mean ± SD*).
| Placebo | Statin Pooled | Pravastatin | Simvastatin | Statin comparisons to placebo | |
|---|---|---|---|---|---|
| n = 342 | n = 674 | n = 338 | n = 336 | ||
| Age (years) | 57.4 ± 12.7 | 56.8 ± 12.0 | 57.1 ± 12.0 | 56.6 ± 12.0 | NS all |
| Sex (% male) | 67.8 | 68.2 | 68.0 | 68.5 | NS all |
| Ethnicity (% white) | 81.9 | 80.9 | 81.7 | 80.1 | NS all |
| Smoker (% current) | 8.77 | 8.01 | 8.58 | 7.44 | NS all |
| Education (scaled 1–9) | 5.72 ± 1.45 | 5.88 ± 1.51 | 5.84 ± 1.47 | 5.91 ± 1.55 | NS all |
| TC (mg/dL) | 229 ± 27.8 | 229 ± 30.2 | 232 ± 30.9 | 226 ± 29.2 | NS all |
| HDL (mg/dL) | 52.5 ± 15.4 | 52.0 ± 15.6 | 53.1 ± 16.2 | 50.8 ± 15.0 | NS all |
| Triglycerides (mg/dL) | 136 ± 79.6 | 136 ± 73.8 | 138 ± 75.1 | 135 ± 72.6 | NS all |
| LDL (mg/dL) | 150 ± 26.1 | 150 ± 25.1 | 152 ± 26.4 | 149 ± 23.6 | NS all |
| Ratio TC / HDL | 4.67 ± 1.24 | 4.73 ± 1.40 | 4.72 ± 1.56 | 4.75 ± 1.21 | NS all |
| Glucose (mg/dL) | 90.0 ± 9.08 | 90.2 ± 9.11 | 89.9 ± 8.65 | 90.5 ± 9.55 | NS all |
| SBP (mm Hg) | 126 ± 14.2 | 127 ± 14.4 | 127 ± 13.7 | 128 ± 15.0 | NS all |
| DBP (mm Hg) | 73.9 ± 8.79 | 75.2 ± 8.80 | 75.4 ± 8.98 | 75.0 ± 8.63 | † |
| Weight (lb) | 185 ± 41.0 | 185 ± 33.6 | 184 ± 33.7 | 186 ± 33.6 | NS all |
| Waist (cm) | 98.2 ± 13.8 | 98.0 ± 11.8 | 97.6 ± 11.6 | 98.3 ± 12.1 | NS all |
| Whole blood serotonin (nM) | 873 ± 335 | 868 ± 322 | 872 ± 342 | 864 ± 302 | NS all |
| Testosterone (ng/ml) | 3.07 ± 2.30 | 3.17 ± 2.31 | 3.18 ± 2.35 | 3.17 ± 2.28 | NS all |
| OASMa | 2.25 ± 5.26 | 2.76 ± 4.73 | 2.81 ± 5.19 | 2.71 ± 4.22 | NS all |
DBP = diastolic blood pressure; HDL = high density lipoprotein cholesterol; LDL = low density lipoprotein cholesterol; NS = nonsignificant; OASMa = Overt-Aggression-Scale-Modified–Aggression-Subscale; SBP = systolic blood pressure; TC = total cholesterol. Except items designated as %.
† DBP: P = 0.04 placebo vs. statin; and P = 0.04 placebo vs. pravastatin.
NS (P>0.1) placebo vs. simvastatin; and simvastatin vs. pravastatin.
Weight and waist circumference were assessed at the screening visit (values shown are for randomized participants only). All other measures were assessed at the baseline visit. Conversion factors: To convert cholesterol (LDL, HDL, TC) from mg/mL to mmol/L, multiply by 0.0259. To convert triglyceride from mg/dL to mmol/L, multiply by 0.0113. To convert glucose from mg/dL to mmol/L, multiply by 0.0555. Baseline OASMa was not predicted by baseline testosterone: β = -0.020 (SE = 0.12) P = 0.87.