Table 9. Regression Including Both Sleep Problems and Testosterone: Both Predict Aggression in Men on Statins and Simvastatin (but Not Pravastatin or Placebo).
Change in Testosterone | Baseline Testosterone | Change in Sleep Problems | Baseline Sleep Problems | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta ± SE | 95% CI | P | Beta ± SE | 95% CI | P | Beta ± SE | 95% CI | P | Beta ± SE | 95% CI | P | |
On Placebo N = 161 | 0.039 ± 0.20 | -0.35, 0.43 | 0.85 | -0.033 ± 0.22 | -0.46, 0.39 | 0.88 | 0.079 ± 0.61 | -1.1, 1.3 | 0.90 | -0.15 ± 0.13 | -0.40, 0.095 | 0.23 |
On Pravastatin N = 152 | -0.076 ± 0.31 | -0.69, 0.54 | 0.81 | -0.24 ± 0.32 | -0.88, 0.40 | 0.46 | 0.26 ± 0.74 | -1.2, 1.7 | 0.72 | 0.13 ± 0.15 | -0.17, 0.44 | 0.39 |
On Statins N = 316 | 0.62 ± 0.29 | 0.041, 1.2 | 0.036 | 0.78 ± 0.30 | 0.19, 1.4 | 0.010 | 2.5 ± 0.59 | 1.3, 3.6 | <0.001 | 0.27 ± 0.15 | -0.024, 0.56 | 0.072 |
On Simvastatin N = 164 | 1.2 ± 0.47 | 0.31, 2.2 | 0.009 | 1.3 ± 0.49 | 0.36, 2.3 | 0.007 | 3.5 ± 0.84 | 1.8, 5.2 | <0.001 | 0.28 ± 0.25 | -0.21, 0.76 | 0.26 |
Beta = regression coefficient; CI = confidence interval; SE = standard error. Findings were nonsignificant for either testosterone or sleep problems (baseline or change) on pravastatin (and on placebo), which did not increase sleep problems and did not significantly reduce testosterone in this study.