Table 2. Main results of the meta-analysis of the pooled OR.
| Variable | Cases/controls (n) | ORb (95% CI) Ph value |
||||
|---|---|---|---|---|---|---|
| Allele(A vs.G) | Homozygote(AA vs.GG) | Heterzygote(AG vs.GG) | Dominant(AA/AG vs.GG) | Recessive(AA vs.AG/GG) | ||
| All subjects | 4656/2654 | 0.914(0.704–1.186)0.499 | 0.903(0.516–1.581)0.722 | 0.854(0.675–1.081)0.189 | 0.865(0.654–1.145)0.312 | 0.982(0.609–1.583)0.939 |
| Primary outcome | ||||||
| CHD | 3896/1892 | 1.056(0.826–1.351)0.663 | 1.223(0.716–2.090)0.461 | 1.053(0.924–1.199)a0.441 | 1.036(0.814–1.320)0.772 | 1.244(0.766–2.021)0.377 |
| MI | 760/762 | 0.674(0.571–0.797)a0.000 | 0.473(0.297–0.753)a0.002 | 0.640(0.517–0.792)a0.000 | 0.618(0.503–0.759)a0.000 | 0.580(0.368–0.916)a0.019 |
| Ethnicity | ||||||
| Asian | 1236/1410 | 0.903(0.500–1.630)0.735 | 0.830(0.237–2.905)0.771 | 0.839(0.553–1.271)0.407 | 0.855(0.477–1.534)0.600 | 0.905(0.304–2.692)0.858 |
| Caucasian | 3420/1244 | 0.916(0.712–1.179)0.497 | 0.922(0.661–1.285)a0.632 | 1.140(0.929–1.398)0.378 | 0.866(0.615–1.219)0.408 | 0.971(0.698–1.351)a0.862 |
Ph, P value for Cochran’s Q test for between-study heterogeneity in each genetic comparison model. a: A fixed effects model was used when the P value for Cochran’s Q test for heterogeneity >0.1. Otherwise, a random effects model was used. b: Crude OR.