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. 2015 Jul 1;10(7):e0131923. doi: 10.1371/journal.pone.0131923

Fig 7. Acute intratracheal administration of clodronate restores HPV in IH rats.

Fig 7

(A) Representative bright-field images and images of immunofluorescent staining using anti-ED-1 antibody of lung sections with or without clodronate. Clodronate (500 μg of clodronate in 100 μL of saline) was injected intratracheally just after the end of the 6-week IH/normoxia exposure period. Calibration bar = 200 μm. (B) Representative microangiographic images of the small pulmonary arteries in the N and IH rats obtained 3 days after the i.t. administration of clodronate. The black arrows point to branches that underwent vasoconstriction. (C) Relationship between vessel size and the extent of the pulmonary vasoconstriction induced in response to acute hypoxia. Data are presented as mean ± S.E.M. values. *Significant change in vessel diameter compared with the baseline conditions (**P<0.01).