Figure 1.

The experimental time line was as follows: cystitis was induced by injection of cyclophosphamide (CYP; 100 mg/kg, i.p.) on Days 1, 3, and 5; an ARTN neutralizing antibody (α-ARTN; 10 mg/kg, i.p.) was administered to one group of mice 30 min prior to CYP on day 1, and to another group of mice 30 min following CYP on day 5. Experimental endpoints were collected from these groups on Days 6 and 13, respectively.