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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: J Pain. 2015 Apr 17;16(7):628–636. doi: 10.1016/j.jpain.2015.03.014

Figure 3.

Figure 3

Treatment with α-ARTN before or after CYP injections prevents and reverses, respectively, CYP-induced bladder hyperalgesia. (A) Relative to controls (open circles), mice treated with CYP exhibited augmented abdominal EMG responses to noxious distension pressure at 1d post-CYP (black circles) that persisted at 7d post-CYP (gray circles). * p<0.05, 1d post-CYP versus control; # p<0.05, 7d post-CYP versus control. (B) At 1d post-CYP, mice pre-treated with IgG (black triangles) exhibited abdominal EMG responses like those of mice treated with CYP alone (panel A). Pre-treatment with α-ARTN prevented the development of hyperalgesia at 1d post-CYP (black squares). Post-treatment with α-ARTN after CYP, when hyperalgesia was already established, reversed CYP-induced hyperalgesia at 7d post-CYP (gray squares). + p<0.05, 1d post-CYP + IgG pre-tx versus control.