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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: J Pain. 2015 Apr 17;16(7):628–636. doi: 10.1016/j.jpain.2015.03.014

Figure 4.

Figure 4

α-ARTN treatment normalizes spinal pERK expression after bladder stimulation and prevents CYP-induced upregulation of MO-responsive bladder afferents and. (A) Spinal neuronal pERK expression (white arrows) in response to noxious bladder distension was significantly increased 1d post-CYP in regions of the dorsal spinal cord receiving lumbosacral bladder afferent input. Pre-treatment with α-ARTN prior to CYP prevented upregulation of distension-evoked spinal pERK. SDH: superficial dorsal horn; DCM: dorsal commissure; CC: central canal; SPN: sacral parasympathetic nucleus. * p<0.05, 1d post-CYP versus naive; + p<0.05, α-ARTN versus 1d post-CYP.