Table 1.
Cohort demographics and numbers
| case | age at death | Final MMSE | sex | ApoE alleles | PMI (h) | Braak stage | CERAD plaque stage | diffuse plaques | neuritic plaques | NFTs | diffuse Lewy bodies |
|---|---|---|---|---|---|---|---|---|---|---|---|
| NC = non-demented control: mean age =86; mean MMSE = 30; Median Braak stage = 2; Median CERAD = 0 | |||||||||||
| 1 | 81 | 30 | M | 3 / 3 | 2.17 | 2 | 0 | 0 | 0 | 0 | 0 |
| 2 | 91 | 30 | M | n/a | n/a | 2 | 0 | 0 | 0 | 1.4 | 0 |
| 3 | 86 | 30 | M | 3 / 3 | 2.17 | 3 | 0 | 0 | 0 | 4.6 | 0 |
| 4 | 93 | 30 | F | 3 / 3 | 2.25 | 2 | 0 | 0 | 0 | 0.25 | 0 |
| 5 | 84 | 30 | M | 2 / 3 | 3.25 | 0 | 0 | n/a | n/a | n/a | 0 |
| 6 | 85 | 30 | M | 3 / 3 | 2 | 3 | 1 | 2 | 0.5 | 8 | 0 |
| 7 | 84 | 30 | F | 3 / 3 | 2.42 | 0 | 0 | 0 | 0 | 0 | 0 |
| 8 | 92 | 30 | F | 2 / 3 | 3.25 | 3 | 2 | 5 | 0 | 0.75 | 0 |
| 9 | 81 | 30 | M | 3 / 4 | 2 | 2 | 2 | 2 | 10.5 | 1 | 0 |
| HS = hippocampal sclerosis of aging: mean age =87; mean MMSE = 22.7; Median Braak stage = 2; Median CERAD = 0 | |||||||||||
| 10 | 74 | 20 | M | 3 / 4 | 8 | 3 | 2 | 0 | 0 | 1.4 | 0 |
| 11 | 95 | 16 | F | 3 / 4 | 3.25 | 3 | 0 | 0 | 0 | 1 | 0 |
| 12 | 87 | 28 | F | 3 / 3 | 1.82 | 3 | 0 | 0 | 0 | 4 | 0 |
| 13 | 84 | 10 | F | n/a | 2.57 | 2 | 0 | 0 | 0 | 0 | 0 |
| 14 | 91 | 29 | F | 2 / 3 | 2.87 | 2 | 1 | 0 | 0 | 6.8 | 0 |
| 15 | 91 | 30 | M | 3 / 3 | 2.83 | 2 | 0 | n/a | n/a | n/a | 0 |
| 16 | 88 | 26 | M | 3 / 4 | 2.33 | 0 | 0 | 0 | 0 | 0 | 0 |
| AD = Alzheimer’s disease: mean age =77; mean MMSE = 11; Median Braak stage = 6; Median CERAD = 3 | |||||||||||
| 17 | 75 | 18 | F | 3 / 4 | 2.5 | 6 | 3 | 9 | 0.33 | 25 | 0 |
| 18 | 84 | 13 | M | 4 / 4 | 5.17 | 6 | 3 | 4 | 1.33 | 26.75 | 0 |
| 19 | 65 | 3 | F | 3 / 4 | 4.1 | 6 | 3 | 2.67 | 1.67 | 41 | 0 |
| 20 | 85 | 4 | F | 3 / 3 | 11.2 | 6 | 3 | 6.67 | 1.33 | 78.8 | 0 |
| 21 | 79 | 6 | M | n/a | 2.08 | 6 | 3 | 4.33 | 2.33 | 25.6 | 0 |
| 22 | 67 | 11 | M | 2 / 3 | 1.75 | 6 | 3 | 0.33 | 0 | 2.4 | + |
| 23 | 82 | 25 | M | n/a | 2.75 | 6 | 2 | 1.67 | 2.67 | 19.8 | + |
| AD + HS: mean age =91; mean MMSE = 7.8; Median Braak stage = 6; Median CERAD = 3 | |||||||||||
| 24 | 96 | 6 | F | 3 / 3 | 6.75 | 6 | 3 | n/a | n/a | n/a | 0 |
| 25 | 91 | 13 | F | 3 / 3 | 3 | 5 | 3 | 6.67 | 1.33 | 34 | 0 |
| 26 | 91 | 12 | F | 4 / 4 | 2.33 | 6 | 3 | 0 | 0 | 10.25 | + |
| 27 | 87 | 0 | F | 3 / 3 | 2.67 | 6 | 3 | 0 | 0 | 54.6 | 0 |
| DLB = Dementia with Lewy bodies: mean age =80; mean MMSE = 17.25; Median Braak stage = 2; Median CERAD = 1 | |||||||||||
| 28 | 65 | 9 | M | 4 / 4 | 9.5 | 2 | 3 | 2 | 7.67 | 2 | + |
| 29 | 61 | 18 | M | 3 / 3 | 2 | 2 | 0 | 0 | 0 | 9.6 | + |
| 30 | 85 | 2 | F | 2 / 3 | 2 | 2 | 3 | 4 | 6.67 | 3.6 | + |
| 31 | 85 | 27 | M | 3 / 3 | 11.2 | 2 | 1 | 0 | 0 | 0.8 | + |
| 32 | 89 | 27 | M | 3 / 3 | 2.42 | 2 | 0 | 0 | 0 | 8.5 | + |
| 33 | 92 | 27 | F | 3 / 4 | 2.42 | 2 | 1 | 0.67 | 0 | 2 | + |
| 34 | 68 | 11 | M | 3 / 4 | 3.75 | 2 | 2 | 0 | 0 | 0.4 | + |
| 35 | 81 | 15 | M | 3 / 3 | 2.42 | 2 | 2 | 1.5 | 2.5 | 0.25 | + |
| 36 | 78 | 9 | M | 3 / 3 | 2.5 | 1 | 0 | 0 | 0 | 2 | + |
| 37 | 81 | 26 | M | 3 / 3 | 5.77 | 1 | 1 | 0 | 0 | 0 | + |
| 38 | 97 | 21 | M | 2 / 3 | 3.5 | 1 | 0 | 0 | 0 | 1.8 | + |
| 39 | 78 | 15 | M | 3 / 4 | n/a | 1 | 1 | 3.5 | 0.5 | 0 | + |
Counts in the hippocampus of neurofibrillary tangles (NFTs), and amyloid plaques, without neurites (diffuse plaques), and with degenerating neurites (neuritic plaques) (see [42]). Abbreviations: Apo E apolipoprotein E; PMI = post-mortem interval; MMSE = mini-mental state examination; +, feature present; n/a = not available