Table 2.

Multivariable predictors of poor diuretic response^a

Covariate	OR	Lower 95% CI	Upper 95% CI	Wald χ2	P-value
Region, Western-like	2.514	1.889	3.347	39.90	<0.0001
Weight (kg)	0.993	0.986	1.000	3.46	0.0630
Diastolic blood pressure (mmHg)	0.988	0.979	0.997	7.30	0.0069
Body temperature (°C)	0.654	0.471	0.910	6.35	0.0117
Respiratory rate (breaths/min)b				6.88	0.0321
Median (21) vs. 25th percentile (19)	0.941	0.878	1.008
75th percentile (24) vs. median (21)	0.976	0.902	1.057
HF hospitalization past year	1.364	1.056	1.763	5.63	0.0176
NYHA class 30 days prior				6.80	0.0779
NYHA II vs. I	0.768	0.551	1.069
NYHA III vs. I	1.135	0.807	1.594
NYHA IV vs. I	1.107	0.711	1.722
Oedema				23.99	<0.0001
Oedema, 1 vs. 0	0.689	0.489	0.970
Oedema, 2 vs. 0	0.531	0.374	0.753
Oedema, 3 vs. 0	0.385	0.258	0.575
Dyspnoea VAS (mm)c				6.72	0.0814
Median (45) vs. 25th percentile (30)	0.867	0.751	1.001
75th percentile (57) vs. median (45)	0.852	0.747	0.971
Percutaneous intervention	1.405	1.069	1.848	5.93	0.0149
Peripheral vascular disease	0.693	0.489	0.983	4.23	0.0397
Hyperthyroid	2.191	1.077	4.458	4.69	0.0304
Atrial fibrillation/flutter at screening	0.733	0.578	0.929	6.59	0.0103
BUN (mmol/L)	1.089	1.052	1.127	23.37	<.0001
Uric acid (µmol/L)	1.001	1.000	1.002	3.75	0.0529
Aspartate aminotransferase, log(U/L)	0.686	0.527	0.893	7.86	0.0050
Sodium (mmol/L)	0.960	0.927	0.993	5.53	0.0187
Potassium (mmol/L)	0.706	0.577	0.864	11.36	0.0007
Total protein (g/L)	1.022	1.003	1.042	4.92	0.0265
NT-proBNP, > median vs. ≤ median	0.735	0.571	0.945	5.76	0.0164
LVEF by serelaxin interaction				4.26	0.0390
LVEF (%), placebo	0.991	0.979	1.003		0.1472
LVEF (%), serelaxin	1.008	0.997	1.020		0.1634

Odds ratios (are for a one unit increase in the covariate unless otherwise specified.

BUN, blood urea nitrogen; CI, confidence interval; HF, heart failure; OR, odds ratio; VAS visual analogue scale.

^aCumulative logit model of diuretic response tertile.

^bNon-linear association modelled as a quadratic polynomial.

^cNon-linear association modelled as a cubic polynomial.