Table 3.
Clinical outcome according to worsening renal function and diuretic response
| Clinical endpoints | No WRF, good diuretic response (n = 389) | No WRF, poor diuretic response (n = 385) | WRF, good diuretic response (n = 136) | WRF, poor diuretic response (n = 138) | Interaction P-value, unadjusted | Interaction P-value, adjusteda |
|---|---|---|---|---|---|---|
| Dyspnoea improvement by VAS AUC to day 5, mean (SD) | 2788.1 (2600.4) | 2356.2 (2735.0) | 2889.2 (3187.7) | 2348.5 (3309.3) | 0.9988 | 0.2024 |
| Cardiovascular death or rehospitalization for HF or renal failure through day 60, n (Kaplan–Meier %) | 29 (7.49) | 66 (17.33) | 13 (9.56) | 26 (19.05) | 0.7362 | 0.7206 |
| Cardiovascular mortality through day 180, n (Kaplan–Meier %) | 23 (5.97) | 26 (6.86) | 10 (7.36) | 16 (11.79) | 0.7238 | 0.5262 |
A good diuretic response is defined as a response greater than the median.
AUC, area under the curve; HF, heart failure; SD, standard deviation; VAS, visual analogue scale; WRF, worsening renal function.
a
Each outcome is adjusted for the covariates given in the footnotes to Table 4.