Table 4.
Associations of diuretic response with selected outcomes
| Unadjusted | Adjusted | ||||
|---|---|---|---|---|---|
| Outcome | Contrast | Measure of association (95% CI) | P-value | Measure of association (95% CI) | P-value |
| Dyspnoea VAS AUC to day 5a | 0.0002 | 0.0001 | |||
| T2 vs. T1 | −355.944 (−751.753, 39.866) | −319.370 (−645.481, 6.740) | |||
| T3 vs. T1 | −855.674 (−1265.072, −446.276) | −749.944 (−1096.009, −403.879) | |||
| CV death or HF/RF rehospitalization through day 60b | <0.0001 | 0.0005 | |||
| T2 vs. T1 | 1.122 (0.702, 1.794) | 0.919 (0.566, 1.494) | . | ||
| T3 vs. T1 | 2.735 (1.806, 4.142) | 1.855 (1.195, 2.879) | . | ||
| CV death through day 180c | 0.1323 | 0.5069 | |||
| T2 vs. T1 | 0.865 (0.502, 1.490) | 0.948 (0.533, 1.689) | . | ||
| T3 vs. T1 | 1.417 (0.856, 2.347) | 1.273 (0.722, 2.244) | . | ||
T1 = first tertile (≤ −0.75 kg/40 mg), T2 = second tertile (> − 0.75 to ≤ −0.22 kg/40 mg), T3 = third tertile (> −0.22 kg/40 mg).
AUC, area under the curve; CI, confidence interval; CV, cardiovascular; HF, heart failure; RF, renal failure; VAS, visual analogue scale.
Measure of association is mean change from linear regression model. Adjusted for age, weight, hypertension, mitral regurgitation, history of atrial fibrillation or flutter, USA-like region, dyspnoea on exertion, body temperature, troponin T, baseline dyspnoea VAS score, uric acid, alkaline phosphatase, and sodium.
Measure of association is hazard ratio from Cox regression model. Adjusted for white race; NYHA class 30 days prior; systolic blood pressure; respiratory rate; number of HF hospitalizations in past year; orthopnoea; asthma, bronchitis, or COPD; hyperthyroid; lymphocyte %; blood urea nitrogen; phosphate; sodium; and total protein.
Measure of association is hazard ratio from Cox regression model. Adjusted for USA-like region, systolic blood pressure, orthopnoea, angina, hyperthyroid, mitral regurgitation, atrial fibrillation or flutter at screening, white blood cell count, lymphocyte %, blood urea nitrogen, sodium, potassium, calcium, total protein, troponin T, and NT-proBNP.