Table 2. Frequency of increased rigidity vs. increased flexibility.
Antibody | Chain | Flexibility increases a | Rigidity increases a | ||
---|---|---|---|---|---|
2.3 ≤ x < 3.3 | 3.3 ≤ x | -3.3 < x ≤ -2.3 | x ≤ -3.3 | ||
whole FABs | |||||
Anti-Fluorescein | H | 6 | 19 | 19 | 3 |
L | 26 | 15 | 23 | 1 | |
Anti-CD3 | H | 2 | 0 | 20 | 29 |
L | 16 | 20 | 5 | 3 | |
Esterase catalytic Ab | H | 2 | 3 | 21 | 37 |
L | 29 | 38 | 3 | 1 | |
Total | 81 | 95 | 91 | 74 | |
Complementarity Determining Regions | |||||
Anti-Fluorescein | H | 0 | 8 | 5 | 0 |
L | 11 | 6 | 0 | 0 | |
Anti-CD3 | H | 0 | 0 | 8 | 11 |
L | 1 | 3 | 0 | 0 | |
Esterase catalytic Ab | H | 0 | 0 | 15 | 10 |
L | 11 | 14 | 0 | 0 | |
Total | 23 | 31 | 28 | 21 | |
CDR H3 | |||||
Anti-Fluorescein | 0 | 0 | 5 | 0 | |
Anti-CD3 | 0 | 0 | 7 | 3 | |
Esterase catalytic Ab | 0 | 0 | 7 | 3 | |
Total | 0 | 0 | 19 | 6 | |
CDR L2 | |||||
Anti-Fluorescein | 5 | 3 | 0 | 0 | |
Anti-CD3 | 4 | 3 | 0 | 0 | |
Esterase catalytic Ab | 5 | 2 | 0 | 0 | |
Total | 14 | 8 | 0 | 0 |
a The counts of amino acids belonging to this classification.