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. 2015 May 8;22(1):30. doi: 10.1186/s12929-015-0133-3

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© Tseng et al. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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SHP deficiency causes non-responsiveness to antidiabetic effect of TZDs. (A, B) Serum glucose (A) and insulin (B) levels under fasting conditions. 7–8 week-old male ob/ob and ob/ob;Shp ^−/− mice were treated with control (open bars) or troglitazone (filled bars) for 2 weeks. (C) Glucose tolerance tests. Intraperitoneal glucose tolerance tests were performed on ob/ob and ob/ob;Shp ^−/− mice treated with control (open symbols) or troglitazone (filled symbols) for 2 weeks. n = 4–5 per group. Data are mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 for differences between control and troglitazone-treated ob/ob mice. #P < 0.01 for differences between ob/ob;Shp ^−/− (with no effect of troglitazone treatment) and control-treated ob/ob mice.