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. 2015 May 8;22(1):30. doi: 10.1186/s12929-015-0133-3

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© Tseng et al. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Expression of lipogenic genes was downregulated by SHP deficiency in ob/ob mice liver. Results in panels A and B are liver mRNA levels for control (open bars) and troglitazone-treated (filled bars) mice after 2 weeks of treatment. Data are expressed as relative fold change after normalized to 36B4 and are mean ± SEM (n = 4–5 per group). By two-way ANOVA, the genotype effect (ob/ob and ob/ob;Shp ^−/−) is significant (P < 0.05) for all except PPARγ1 in panel A. The treatment effect and genotype × treatment interaction is significant for CD36, aP2, FAS, ACC1 and PEPCK in panel B.