TABLE II. LTF Arg47Lys polymorphism allele, genotype frequencies (and counts) in human immunodeficiency virus (HIV) positive (+) and negative (-) children in the four different populations analysed.
| LTF SNP Arg47Lys (rs1126478) | HIV- | HIV+ | HIV- vs. HIV+ p (CI) OR |
|---|---|---|---|
| Africa | n = 15 | n = 26 | |
| G | 0.97 (29) | 0.96 (50) | Reference |
| A | 0.03 (1) | 0.04 (2) | 1.00 (0.06-70.74) 1.16 |
| G/G | 0.93 (14) | 0.96 (25) | Not calculable |
| A/G | 0.07 (1) | 0.00 (0) | Not calculable |
| A/A | 0.00 (0) | 0.04 (1) | Not calculable |
| HWE (χ2; p) | 0.02; 0.89 | 26; 3.41E-07 | |
| India | n = 31 | n = 45 | - |
| G | 0.66 (41) | 0.64 (58) | Reference |
| A | 0.34 (21) | 0.36 (32) | 0.86 (0.52-2.26) 1.08 |
| G/G | 0.39 (12) | 0.38 (17) | Reference |
| A/G | 0.55 (17) | 0.53 (24) | 1.00 (0.34-2.90) 0.99 |
| A/A | 0.06 (2) | 0.09 (4) | 1.00 (0.17-17.82) 1.40 |
| HWE (χ2; p) | 1.56; 0.21 | 1.21; 0.27 | - |
| Brazil | n = 35 | n = 78 | |
| G | 0.57 (40) | 0.67 (104) | Reference |
| A | 0.43 (30) | 0.33 (52) | 0.18 (0.36-1.24) 0.67 |
| G/G | 0.40 (14) | 0.49 (38) | Reference |
| A/G | 0.34 (12) | 0.36 (28) | 0.82 (0.31-2.38) 0.86 |
| A/A | 0.26 (9) | 0.15 (12) | 0.26 (0.15-1.64) 0.50 |
| HWE (χ2; p) | 3.15; 0.08 | 2.88; 0.09 | - |
| Italy | n = 18 | n = 89 | |
| G | 0.36 (13) | 0.40 (71) | Reference |
| A | 0.64 (23) | 0.60 (107) | 0.71 (0.53-2.70) 1.17 |
| G/G | 0.06 (1) | 0.16 (14) | Reference |
| A/G | 0.61 (11) | 0.48 (43) | 0.79 (0.20-2.45) 0.73 |
| A/A | 0.33 (6) | 0.36 (32) | 0.66 (0.27-129.16) 2.58 |
| HWE (χ2; p) | 1.89; 0.17 | 0.005; 0.94 | - |
CI: confidence interval; HWE: Hardy Weinberg equilibrium; LTF: lactoferrin encoding gene; OR: odds ratio; SNP: single nucleotide polymorphism.