TABLE III. LTF Thr29Ala polymorphism allele, genotype frequencies (and counts) in human immunodeficiency virus (HIV) positive (+) plus negative (-) children in the four different populations compared with the most similar ethnic group reported by HapMap and 1000 Genomes project.
| LTF SNP Thr29Ala (rs1126477) | Total (HIV+ plus HIV-) | HapMap/ 1000 Genomes | Total vs. Hapmap/ 1000 Genomes p (CI) OR |
|---|---|---|---|
| Africa (n = 41) | HapMap-YRIa (n = 113) | ||
| A | 0.77 (63) | 0.85 (192) | Reference |
| G | 0.23 (19) | 0.15 (34) | 0.12 (0.85-3.32) 1.70 |
| A/A | 0.61 (25) | 0.70 (79) | Reference |
| A/G | 0.32 (13) | 0.30 (34) | 0.69 (0.50-2.80) 1.21 |
| G/G | 0.07 (3) | 0.00 (0) | Not calculable |
| India (n = 76) | 1000 Genomes-ASNb (n = 286) | ||
| A | 0.42 (64) | 0.40 (229) | Reference |
| G | 0.58 (88) | 0.60 (343) | 0.64 (0.63-1.34) 0.92 |
| A/A | 0.14 (11) | 0.17 (49) | Reference |
| A/G | 0.55 (42) | 0.46 (131) | 0.38 (0.65-3.32) 1.43 |
| G/G | 0.30 (23) | 0.37 (106) | 1.00 (0.41-2.38) 0.97 |
| Brazil (n = 113) | 1000 Genomes-AMRc (n = 199) | ||
| A | 0.52 (117) | 0.41 (149) | Reference |
| G | 0.48 (109) | 0.59 (213) | 0.01 (0.46-0.92) 0.65 |
| A/A | 0.32 (36) | 0.19 (34) | Reference |
| A/G | 0.40 (45) | 0.45 (81) | 0.03 (0.28-0.99) 0.53 |
| G/G | 0.28 (32) | 0.36 (66) | 0.02 (0.23-0.90) 0.46 |
| Italy (n = 107) | HapMap-TSId (n = 88) | ||
| A | 0.30 (64) | 0.26 (46) | Reference |
| G | 0.70 (150) | 0.74 (130) | 0.43 (0.52-1.32) 0.83 |
| A/A | 0.11 (12) | 0.06 (5) | Reference |
| A/G | 0.37 (40) | 0.41 (36) | 0.27 (0.12-1.60) 0.47 |
| G/G | 0.51 (55) | 0.53 (47) | 0.29 (0.13-1.63) 0.49 |
a: Yoruba, Ibadan, Nigeria; b: an admixture from Han-Chinese in Beijng, China, Southern Han Chinese, Japanese in Tokyo, Japan; c: an admixture of Colombian from Medellin, Colombia, Mexican ancestry from Los Angeles, United States of America, Puerto Ricans, from Puerto Rico; d: Toscans, Italy; CI: confidence interval; LTF: lactoferrin encoding gene; OR: odds ratio; SNP: single nucleotide polymorphism.