TABLE IV. LTF Arg47Lys polymorphism allele, genotype frequencies (and counts) in human immunodeficiency virus (HIV) positive (+) plus negative (-) children in the four different populations compared with the most similar ethnic group reported by HapMap and 1000 Genomes project.
| LTF SNP Arg47Lys (rs1126478) | Total (HIV+ plus HIV-) | HapMap/ 1000 Genomes | Total vs. Hapmap/ 1000 Genomes p (CI) OR |
|---|---|---|---|
| Africa (n = 41) | HapMap-YRIa (n = 113) | ||
| G | 0.97 (79) | 0.99 (223) | Reference |
| A | 0.03 (3) | 0.01 (3) | 0.19 (0.37-21.43) 2.81 |
| G/G | 0.93 (39) | 0.97 (110) | Reference |
| A/G | 0.07 (1) | 0.03 (3) | 1.00 (0.02-12.11) 0.94 |
| A/A | 0.00 (1) | 0.00 (0) | Not calculable |
| India (n = 76) | 1000 Genomes-ASNb (n = 286) | ||
| G | 0.66 (99) | 0.65 (371) | Reference |
| A | 0.34 (53) | 0.35 (201) | 1.00 (0.66-1.46) 0.99 |
| G/G | 0.39 (29) | 0.43 (124) | Reference |
| A/G | 0.55 (41) | 0.43 (123) | 0.22 (0.81-2.54) 1.42 |
| A/A | 0.06 (6) | 0.14 (39) | 0.51 (0.21-1.78) 0.66 |
| Brazil (n = 113) | 1000 Genomes-AMRc (n = 199) | ||
| G | 0.57 (144) | 0.47 (169) | Reference |
| A | 0.43 (82) | 0.53 (193) | 0.00006 (0.35-0.71) 0.50 |
| G/G | 0.40 (52) | 0.24 (44) | Reference |
| A/G | 0.34 (40) | 0.45 (81) | 0.002 (0.23-0.75) 0.42 |
| A/A | 0.26 (21) | 0.31 (56) | 0.0004 (0.16-0.63) 0.32 |
| Italy (n = 107) | HapMap-TSId (n = 88) | ||
| G | 0.36 (84) | 0.33 (59) | Reference |
| A | 0.64 (130) | 0.67 (117) | 0.25 (0.50-1.21) 0.78 |
| G/G | 0.06 (15) | 0.10 (9) | Reference |
| A/G | 0.61 (54) | 0.47 (41) | 0.65 (0.28-2.16) 0.79 |
| A/A | 0.33 (38) | 0.43 (38) | 0.35 (0.20-1.68) 0.60 |
a: Yoruba, Ibadan, Nigeria; b: an admixture from Han-Chinese in Beijng, China, Southern Han Chinese, Japanese in Tokyo, Japan; c: an admixture of Colombian from Medellin, Colombia, Mexican ancestry from Los Angeles, United States of America, Puerto Ricans, from Puerto Rico; d: Toscans, Italy; CI: confidence interval; LTF: lactoferrin encoding gene; OR: odds ratio; SNP: single nucleotide polymorphism.