TABLE II. Flexible amino acids of the active sites from the mammalian and parasite enzymes.
| 1IWO |
PfATP6 |
|||||
|---|---|---|---|---|---|---|
| Residue | Symbol | Position | Residue | Symbol | Position | |
| Leucine | LEU | 253 | Isoleucine | ILE | 251 | |
| Glutamate | GLU | 255 | Leucine | LEU | 253 | |
| Phenylalanine | PHE | 256 | Phenylalanine | PHE | 254 | |
| Glutamine | GLN | 259 | Glutamine | GLN | 257 | |
| Leucine | LEU | 260 | Leucine | LEU | 258 | |
| Valine | VAL | 263 | Isoleucine | ILE | 261 | |
| Isoleucine | ILE | 761 | Isoleucine | ILE | 748 | |
| Isoleucine | ILE | 765 | Isoleucine | ILE | 752 | |
| Aspartate | ASN | 768 | Aspartate | ASN | 755 | |
| Valine | VAL | 769 | Isoleucine | ILE | 756 | |
| Valine | VAL | 772 | Valine | VAL | 759 | |
| Valine | VAL | 773 | Phenylalanine | PHE | 763 | |
| Phenylalanine | PHE | 776 | Leucine | LEU | 815 | |
| Leucine | LEU | 828 | Isoleucine | ILE | 816 | |
| Isoleucine | ILE | 829 | Leucine | LEU | 821 | |
| Phenylalanine | PHE | 834 | Tyrosine | TYR | 824 | |
| Tyrosine | TYR | 837 | Isoleucine | ILE | 825 | |
| Methionine | MET | 838 | - | - | - | |