Figure 1. Transiently reduced expression of caveolin-1 in heart following cryoinjury.
A) Cav1 mRNA abundance in cryoinjured WT mice was transiently decreased, compared to sham-operated mice. Gene expression was assessed by TaqMan assay and normalized to ß-actin. WT sham group value has been used for normalization among study groups. Bar represents mean ± SD. ***= p<0.001, n= 7. B) Measure of level of cav1 protein expression in sham and 3-day post cryoinjured hearts. In insert, a representative western blot from which these data were derived. C) Representative immunohistochemistry staining for cav1. This protein is robustly expressed in endothelial cells in sham LV (left), while protein levels dramatically decrease at 3 days after cryoinjury (middle) and are returned towards control at day 14 (right).
