Table 1.
Inflammatory responses after cryoinjury.
WT | Cav1−/− | ||||||||
---|---|---|---|---|---|---|---|---|---|
sham | 3d | 14d | 30d | sham | 3d | 14d | 30d | ||
Infiltrating cell | Neutrophil (cells/625μm2) | 1.38 ± 0.23 | 54.3 ± 11.4 | 1.00 ± 0.25 | 3.03 ± 0.68 | 1.05 ± 0.20 | 59.9 ± 2.5 | 0.850 ± 0.187 | 2.35 ± 0.38 |
Macrophage (cells/625μm2) | 4.43 ± 1.89 | 111 ± 16 | 64.1 ± 29.0 | 9.76 ± 3.36 | 1.32 ± 0.40 | 98.4 ± 26.7 | 6.75 ± 3.84 | 4.10 ± 1.82 | |
Cytokine | IL-1β | 1 | 2.38 ± 0.24 | 0.962 ± 0.202 | 1.59 ± 0.37 | 1.52 ± 0.45 | 1.93 ± 0.48 | 1.32 ± 0.12 | 0.869 ± 0.164 |
IL-6 | 1 | 6.38 ±1.23 | 0.825 ± 0.207 | 2.85 ± 21 | 2.39 ± 0.74 | 11.8 ± 3.5 | 3.47 ± 0.33 | 1.95 ± 0.17 | |
TNF-α | 1 | 2.79 ± 0.74 | 2.92 ± 0.35 | 1.15 ± 0.23 | 2.38 ± 0.92 | 2.17 ± 0.51 | 1.74 ± 0.15 | 1.21 ± 0.28 | |
TGF-β | 1 | 0.712 ± 0.012 | 1.267 ± 0.07 | 1.27 ± 0.07 | 1.24 ± 0.10 | 1.06 ± 0.10 | 2.14 ± 0.33 | 1.38 ± 0.12 |
Upper part:Neutrophils and macrophages were identified by immunohistochemistry in injured WT and Cav1−/− knockout (Cav1−/−) hearts after 3 days, 14 days, and 30 days after cryoinjury. Lower part: Expression of proinflammatory cytokines in the whole heart of WT and Cav1−/− knockout after 3 days, 14 days, and 30 days after cryoinjury.