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. Author manuscript; available in PMC: 2016 Jul 28.
Published in final edited form as: J Control Release. 2015 May 21;210:208–216. doi: 10.1016/j.jconrel.2015.05.278

Fig 2. Stability and immunogenicity of M2e5x vaccines coated onto MNs.

Fig 2

M2e5x vaccines coated onto MN were preserved in 4°C or R.T. for 4 or 8 weeks. Stability of M2e5x VLPs was measured by reactivity to M2e monoclonal antibody (14C2) using enzyme-linked immunosorbent assay (ELISA). (A) Stability of M2e5x VLP coated onto MNs stored at different temperatures. (B) Immunogenicity of M2e5x VLP coated MNs stored at different temperatures. BALB/c mice (N=5) were immunized by delivering M2e5x VLP MNs to the skin. Sera were collected 3 weeks after prime (p) and boost (b) vaccination. (C) Stability of M2e4x proteins coated onto MNs. Asterisk indicates significant differences between M2e5x VLP and M2e5x protein (*: <0.01). Error bars indicate mean ± SEM.