Skip to main content
. Author manuscript; available in PMC: 2015 Jul 2.
Published in final edited form as: J Pharmacol Sci. 2015 Jan 5;127(1):10–16. doi: 10.1016/j.jphs.2014.12.013

Fig. 1.

Fig. 1

Sigma-1 receptor reduces motoneuron excitability and slows ALS progression. A. Frequency-current relationships in motoneurons of SR1 KO (red) and WT (blue) mice. A significant increase in the slope of FeI relationship was apparent in S1R KO mice at current intensities > 700 pA (p < 0.05). Bars are ± standard errors. Number of recordings per intensity is shown above/below standard error bars. B. Kaplane-Meyer end stage curve. Median survival of mice is 186.0 days for ALS S1R WT mice (blue), and 127.0 days for ALS S1R KO mice (red). p < 0.0001; χ2 = 32.29. Modified with copyright permission from: Mavlyutov et al., Neuroscience 2013; 240:129–34.