Table 1.

Summary of Acquired and Germline Alterations in Adult Gliomas.^*

Alteration Type	Triple-Positive	TERT and IDH Mutation	IDH Mutation Only	Triple-Negative	TERT Mutation Only
Grouping alterations	IDH, 1p/19q, and TERT	TERT and IDH	IDH	—	TERT
Common acquired mutations	CIC, FUBP1, NOTCH1, and PIK3CA or PIK3R1	TP53 and ATRX	TP53 and ATRX	EGFR, PTEN, and NF1	EGFR, EGFRvIII, PTEN, NF1, RB1, and PIK3CA or PIK3R1
Common acquired copy-number alterations	Loss of chromosome 4, hemizygous loss of CDKN2A/B; “genomically quiet”	Gain of chromosome 7, duplication of 8q24 (MYC), homozygous loss of CDKN2A/B, deletion of PTEN	Duplication of 7q, duplication of 8q24 (MYC), hemizygous loss of CDKN2A/B, deletion of 19q (without deletion of 1p)	Similar to TERT mutation only (at lower prevalence)	Loss of chromosome 4, gain of chromosome 7, gain of chromosome 19, amplification of EGFR, homozygous loss of CDKN2A/B, deletion of PTEN, other amplifications
TCGA glioblastoma expression subtype	Proneural	Mesenchymal, neural, proneural	Proneural	Classical, mesenchymal, neural, proneural	Classical, mesenchymal
Germline SNPs	8q24	8q24, TP53 3′ untranslated region	8q24, PHLDB1	CDKN2A/B, RTEL1, TERT	CDKN2A/B, RTEL1, TERT, TERC

^*SNP denotes single-nucleotide polymorphism, and TCGA the Cancer Genome Atlas.