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. 2015 Jun 26;11:343–351. doi: 10.2147/VHRM.S63060

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© 2015 Chan et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Clinical efficacy and safety of betrixaban in Phase II EXPERT trial.

Notes: The EXPERT trial was a Phase II study comparing oral betrixaban 15 mg bid (BE15), and 40 mg bid (BE40) with enoxaparin 30 mg bid sc (ENOX30) in patients undergoing total knee replacement. All VTE (blue bars) occurred in 20% (95% CI: 11.4%–31.3%), 15% (95% CI: 7.6%–26.5%), and 10% (95% CI: 2.8%–23.7%) of patients receiving betrixaban 15 mg bid, 40 mg bid, and enoxaparin 30 mg bid, respectively. The corresponding clinically relevant bleeding rates (red bars) were 0% (95% CI: 0%–4.2%), 2.4% (95% CI: 0.3%–8.3%), and 7.0% (95% CI: 1.5%–19.1%), respectively.

Abbreviations: VTE, venous thromboembolism; CRNM, clinically relevant non-major; CI, confidence interval.