Table 4. Characteristics of the Pakistani sample sets.
| Islamabad | Lahore | |||||
|---|---|---|---|---|---|---|
| Trait | ControlsN = 228 | CasesN = 321 | p-value | ControlsN = 219 | CasesN = 404 | p-value |
| Age (mean) | 38(11.83) | 53(11.80) | <2.2x10-16 | 56 (10.50) | 59 (12.60) | 2x10-3 |
| Gender (% Female) | 34% | 31% | 0.52 | 46% | 41% | 0.27 |
| BMI (kg/m2) | 24.2(3.95) | 24.3(4.08) | 0.85 | - | - | - |
| TC (mmol/l) | 4.52(1.38) | 4.71(3.77) | 0.56 | - | - | - |
| LDL-C (mmol/l) | 2.66(0.78) | 2.55(0.99) | 0.33 | 2.19 (0.44) | 2.74 (0.75) | 6.50x10-22 |
| HDL-C (mmol/l) | 1.35(1.01) | 0.96(0.22) | 1.01x10-4 | - | - | - |
| TG (mmol /l)* | 1.44 (0.91) | 1.58 (1.06) | 0.22 | - | - | - |
| Diabetes (%) | 1 | 32 | 6.6x10-9 | 14 | 65 | 5.10x10-34 |
| Hypertension (%) | 15 | 46 | 4.9x10-7 | 16 | 62 | 9.00x10-28 |
| Family History (%) | 42 | 42 | 0.96 | - | - | - |
| Smoking (%) | 25 | 46 | 1.25x10-3 | 11 | 30 | 4.30x10-8 |
| 19 SNP Gene Score | 2.89 (0.50) | 2.94(0.50) | 0.35 | 2.92(0.53) | 2.93(0.50) | 0.75 |
| 13 SNP Gene Score | 2.24(0.42) | 2.34(0.42) | 0.04 | 2.21(0.39) | 2.21(0.39) | 0.95 |
Categorical variables were compared using a χ2 test while continuous variables were compared using Welch’s t-tests.
* Log transformed data. Geometric mean and approximate SD are given.