Table 2.

Reasons for prematurely discontinuing medication

Adverse Event	TMP/SMZ	Dapsone
Total	n=63	n=14
Drug allergy or non-infectious fever	25% (16)
Unknown/Not documented	25% (16)	50% (7)
Elevated liver function tests*	21% (13)
Hematologic process**	16% (10)	29% (4)
Acute interstitial nephritis	11% (7)	7% (1)
Hyperkalemia	4% (3)
Acute Kidney Injury	4% (1)
Poor Appetite		7% (1)
Oral Ulcers		7% (1)

Patients were considered to have stopped antibiotics prematurely if they discontinued TMP/SMZ or dapsone more than 30 days prior to reaching the 180 day post-transplant mark.

^*Aspartate aminotransferas (AST) or alanine aminotransferase (ALT) greater than three times the upper limit of normal

^**Hematologic processes included prolonged leucopenia or anemia