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. 2015 Jul 2;10(7):e0132075. doi: 10.1371/journal.pone.0132075

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Fig 5 — Triple immunofluorescence staining for different components of perineuronal nets, revealed by a confocal laser scanning microscope. In the control case, omnipause neurons (OPN) are ensheathed by prominent perineuronal nets showing the same appearance with antibodies against the link protein (HPLN1), chondroitin sulfate proteoglycan (CSPG) and aggrecan (ACAN) (A, D, G, arrow). In the saccadic palsy patient, the neurons of the superior olive (SO) from the same sections as OPN are ensheathed by prominent perineuronal nets revealed by immunostaining of HPLN1, CSPG, and ACAN (C, F, I, arrows). However, around OPN (asterisk) in the patient, only HPLN1-based perineuronal nets can be detected, which appear fragmented (B, arrow). CSPG- and ACAN-immunostaining does not reveal perineuronal nets, but only few fragments along a few dendrites (E, H, arrow). Scale bars A,D,G = 20μm; B,C,E,F,H,I = 200μm.