Table 4. Repeated measures analysis of variance (ANOVA) for haemostatic variables in the titration group and in the control group preoperatively and 10min, 2h and 4h after cardiopulmonary bypass.

	Titration group	Control group	p value group	p value time	p value group/time interaction
Antithrombin (kIU/L)			0.78	< 0.001	0.36
Preoperative	0.88 (0.73–1.19)	0.86 (0.66–1.15)
10 min after CPB	0.69 (0.37–0.89)	0.69 (0.53–0.93)
2 hours after CPB	0.73 (0.60–1.00)	0.73 (0.50–1.10)
4 hours after CPB	0.76 (0.60–0.90)	0.76 (0.48–1.04)
Anti Xa (kIU/L)			0.29	< 0.001	0.87
Preoperative	0.04 ± 0.09	0.05 ± 0.09
10 min after CPB	0.05 ± 0.11	0.09 ± 0.11
2 hours after CPB	0.09 ± 0.11	0.13 ± 0.15
4 hours after CPB	0.14 ± 0.13	0.16 ± 0.15
ACT (s)			0.99	0.41	0.036
Preoperative	125 ± 16*	117 ± 12
10 min after CPB	116 ± 14*	123 ± 12
2 hours after CPB	122 ± 10	126 ± 12
4 hours after CPB	121 ± 12	124 ± 12
Haemoglobin (g/L)			0.7	<0.001	0.52
Preoperative	128 ± 12	128 ± 10
10 min after CPB	104 ± 11	107 ± 10
2 hours after CPB	109 ± 16	107 ± 18
4 hours after CPB	109 ± 14	111 ± 13
Platelet count (x109/L
Preoperative	227 ± 59	217 ± 4	0.63	<0.001	0.96
10 min after CPB	152 ± 44	148 ± 57
2 hours after CPB	188 ± 65	183 ± 49
4 hours after CPB	196 ± 60	185 ± 46
PT (INR
Preoperative	1.2 ± 0.1	1.2 ± 0.1	0.47	<0.001	0.98
10 min after CPB	1.3 ± 0.1	1.3 ± 0.1
2 hours after CPB	1.3 ± 0.1	1.3 ± 0.1
4 hours after CPB	1.2 ± 0.1	1.3 ± 0.1
aPTT (s)
Preoperative	36 ± 3	36 ± 3	0.91	<0.001	0.94
10 min after CPB	39 ± 6	39 ± 4
2 hours after CPB	41 ± 7	40 ± 7
4 hours after CPB	46 ± 11	46 ± 11
Thrombin time (s)			0.59	<0.001	0.79
Preoperative	17 ± 1	17 ± 1
10 min after CPB	48 ± 108	39 ± 62
2 hours after CPB	33 ± 31	34 ± 48
4 hours after CPB	64 ± 111	47 ± 47

Key: Data presented as mean and standard deviation or median and range. ACT–activated clotting time, aPTT–activated partial thromboplastin time CPB–cardiopulmonary bypass, INR–International normalized ratio, PT–prothrombin time.