Table 1. Coagulation Test.

TCT, Fibrinogen, aPTT and bleeding time was assessed in all groups at baseline, T6, and days 2, 6, 14 and 21. CTR: control group; anti-Psel-Aptamer-Px: P-selectin inhibitor prophylaxis group; anti-Psel-Aptamer-Tx: P-selectin inhibitor treatment group; LMWH-Tx: Low molecular weight heparin treatment group; anti-VWF-Aptamer-Px: von Willebrand factor prophylaxis group; anti-VWF-Aptamer-Tx: von Willebrand factor inhibitor treatment group. Base: Baseline; T6: 6 hours after thrombosis, D2: two days after thrombosis; D6: six days after thrombosis; D14: fourteen days after thrombosis; D21: twenty-one days after thrombosis. In bold: values out of range.

TCT (seconds)
	CONTROL	P-sel PX	P-sel TX	VWF PX	VWF TX	LMWH
BASELINE	17.1	17.2	16.8	15.2	17.8	17.7
T6	15.7	17.2	15.3	15.2	16.4	16.2
D2	18.3	20.6	19.1	20.6	20.1	78.0
D6	20.6	19.4	19.0	19.0	19.0	42.9
D14	18.5	18.4	18.2	17.7	20.5	58.7
D21	17.0	17.1	17.6	17.0	18.2	17.7

Fibrinogen (mg/dL)
	CONTROL	P-sel PX	P-sel TX	VWF PX	VWF TX	LMWH
BASELINE	186.7	138.8	193.2	147.5	193.5	210.0
T6	133.5	120.8	134.3	153.8	128.5	160.4
D2	321.7	352.5	349.7	450.0	333.3	632.5
D6	298.3	265.0	247.2	300.0	246.7	463.3
D14	185.0	163.0	180.0	177.5	118.0	232.3
D21	163.3	148.8	158.5	165.0	144.7	193.3

aPTT (seconds)
	CONTROL	P-sel PX	P-sel TX	VWF PX	VWF TX	LMWH
BASELINE	30.0	31.3	31.8	33.7	22.5	29.8
T6	35.8	34.7	36.1	34.6	36.0	37.1
D2	40.4	42.0	42.7	34.5	40.7	55.8
D6	29.7	28.7	30.8	25.8	27.9	32.7
D14	33.1	31.0	31.6	27.4	30.3	33.3
D21	30.5	31.9	32.9	29.0	29.1	29.4

Bleeding Time (minutes)
	CONTROL	P-sel PX	P-sel TX	VWF PX	VWF TX	LMWH
BASELINE	3.0	2.1	2.3	2.5	2.5	1.8
T6	3.5	3.6	3.1	24.3	4.8	2.8
D2	4.5	3.9	4.4	11.0	20.0	7.5
D6	4.8	2.6	3.4	6.7	15.7	4.3
D14	4.2	2.3	3.1	2.5	6.7	2.2
D21	2.8	2.4	3.4	2.5	2.5	2.2