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. 2015 Jul 3;4:312. doi: 10.1186/s40064-015-1106-4

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© Chou et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Inhibitory effects of lmw-chitosan on MG in vitro and in vivo. a Lmw-chitosan binds to MG and decreases the level of MG in vitro. The inhibition curve of lmw-chitosan on MG binding is shown. The concentration necessary to achieve 50% inhibition was 4.60 µg mL⁻¹, n = 3. b Group C represents the control group. Group A was induced by AA (10 mg kg⁻¹ day⁻¹) for 5 days. Group AM represents lmw-chitosan-treated AAN mice. Group M represents normal mice treated with lmw-chitosan. MG levels were observed to increase in AAN mice; however, this increase is reversed in lmw-chitosan-treated AAN mice. *p < 0.05, compared to Group C; ^# p < 0.05, compared to Group A, n = 5–6.