. Author manuscript; available in PMC: 2016 Jul 1.

Published in final edited form as: Cancer Chemother Pharmacol. 2015 May 17;76(1):85–96. doi: 10.1007/s00280-015-2768-x

Table 2.

Variability in F-ara-A AUC and F-ara-ATP accumulation rate

Biomarker	N	Mean ± SD (range)
F-ara-A AUC (μM×h) dose 1^a	100	19.6 ± 4.80 (9.96 – 36.4)
Variability in 24hr F-ara-A concentration
Within-patient CV	88^a	28 ± 13% (0.5 – 63)
Within-patient maximum/minimum	88^a	1.8 ± 0.4 (1.0 – 3.7)
F-ara-ATP accumulation rate (pmol/10⁶ cells/4h)
in CD4⁺ cells	36	4.6 ± 2.1 (0.7 – 9.4)
in CD8⁺ cells	34	4.0 ± 2.4 (0.3 – 11.6)

Abbreviations: AUC: Area under the concentration-time curve; CV: coefficient of variation; F-ara-A: 9-β-D-arabinofuranosyl-2-fluoroadenine; F-ara-ATP: fludarabine triphosphate.

Dose 1 administered on HCT day −4.