Figure 3.
Proximity of RIS to TSS of proto-oncogenes in cancer gene lists. (a) Leukemia (n = 682) (b) Retrovirus and Transposon Tagged Cancer Gene Database (RTCGD) and the Catalogue of Somatic Mutations in Cancer (COSMIC) (n = 943). (c) Network of Cancer Genes 4.0 (NCG 4.0) (n = 2048). (d) Proportion of RIS within NCG 4.0 proto-oncogene transcripts or within 50 kb of a proto-oncogene TSS. In vivo low and in vivo high represent the lowest and highest thirds of RIS ranked by recovery frequency. Abbreviations: ns, not significant; RIS, retroviral insertion site; TSS, transcription start site.