Fig. 10.
(A) Selected end states of the αS monomers across the 20 HMMM membrane-binding simulations conducted, highlighting the variability of αS when bound to the membrane. (B) Inter-helix angle (θh) for all 20 membrane-binding simulations. θh is defined by the angle between the two vectors formed by a linear interpolation of the α carbons of the N- and C-helices. θh distinguishes between two states, a broken helix state where θh never exceeds 47°, and a semi-extended intermediate state where the inter-helix angle is approximately 90°. Originally published in Vermaas and Tajkhorshid (2014a), used with permission from Elsevier B.V.