Table 5.
Salivary Biomarkers (pg/ml) Identified in AI Users and Controls
| Biomarker (pg/ml) | Group (n=29 per group) | Median | Range | P Value* |
|---|---|---|---|---|
| CRP | Not on AI | 888 | 12 to 10,513 | |
| On AI | 1,481 | 25 to 10,137 | 0.13 | |
| IL-1a | Not on AI | 214 | 44 to 4,794 | |
| On AI | 262 | 44 to 3,561 | 0.28 | |
| IL-1b | Not on AI | 69 | 0 to 1,224 | |
| On AI | 1,51 | 4 to 1,319 | 0.89 | |
| IL-6 | Not on AI | 59 | 0 to 239 | |
| On AI | 42 | 2 to 332 | 0.90 | |
| IL-8 | Not on AI | 265 | 56 to 1,253 | |
| On AI | 335 | 50 to 978 | 0.71 | |
| IL-10 | Not on AI | 214 | 0 to 552 | |
| On AI | 220 | 96 to 488 | 0.82 | |
| IL-17 | Not on AI | 32 | 0 to 103 | |
| On AI | 25 | 0 to 85 | 0.48 | |
| IL-18 | Not on AI | 320 | 35 to 12,038 | |
| On AI | 463 | 34 to 13,085 | 0.48 | |
| MCP-1 | Not on AI | 1,421 | 280 to 6,335 | |
| On AI | 1,842 | 428 to 4,736 | 0.76 | |
| MMP-8 | Not on AI | 7,206 | 3,875 to 9,840 | |
| On AI | 7,076 | 4,550 to 8,929 | 0.98 | |
| MMP-9 | Not on AI | 38,883 | 21,159 to 53,477 | |
| On AI | 38,034 | 13,646 to 52,003 | 0.54 | |
| OPG | Not on AI | 4,174 | 896 to 32,616 | |
| On AI | 4,848 | 123 to 41,012 | 0.67 | |
| Osteocalcin | Not on AI | 121 | 47 to 405 | |
| On AI | 182 | 72 to 323 | 0.03† | |
| SDF-1α | Not on AI | 270 | 23 to 15,415 | |
| On AI | 508 | 35 to 16,803 | 0.59 | |
| TNFa | Not on AI | 2 | 0 to 27 | |
| On AI | 9 | 0 to 632 | 0.003† | |
| RANKL | Not on AI | 1,110 | 0 to 7,028 | |
| On AI | 1,861 | 0 to 5,194 | 0.058 | |
| VEGF | Not on AI | 3,410 | 1,714 to 7,957 | |
| On AI | 3,276 | 539 to 7,683 | 0.59 |
*
Wilcoxon test of rank sum used to test the median of means
†
Significant differences between groups
IL, Interleukin; MCP-1, Monocyte Chemoattractant Protein-1; MMP, matrix metalloproteinases; SDF-1α, stromal cell-derived factor 1α; TNFα, Tumor necrosis factor; RANKL, Receptor activator of nuclear factor-kappa β ligand.