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Gadolinium plasma pharmacokinetic parameters after intraperitoneal (IP) or intravenous (IV) administration of nanoemulsion (NE) formulations in nu/nu mice, (n=3).
| Group | Route | t1/2 (h) | Tmax (h) | Cmax (μg/mL) | Vd (mL/kg) | Cl (mL/h/kg) | MRT (h) | AUClast (h*μg/mL) |
|---|---|---|---|---|---|---|---|---|
| Non-targeted NE | IP | 8.5 | 3 | 11 | 1142 | 93 | 12 | 106 |
| EGFR-targeted NE | IP | 7.7 | 3 | 16 | 894 | 80 | 10 | 130 |
| Non-targeted NE | IV | 8.7 | 0.08 | 32 | 1185 | 94 | 12 | 99 |
| EGFR-targeted NE | IV | 5.9 | 0.5 | 27 | 696 | 81 | 8 | 131 |
