Skip to main content
. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Pharm Res. 2015 Mar 4;32(8):2753–2763. doi: 10.1007/s11095-015-1660-z

Table III.

Gadolinium plasma pharmacokinetic parameters after intraperitoneal (IP) or intravenous (IV) administration of nanoemulsion (NE) formulations in nu/nu mice, (n=3).

Group Route t1/2 (h) Tmax (h) Cmax (μg/mL) Vd (mL/kg) Cl (mL/h/kg) MRT (h) AUClast (h*μg/mL)
Non-targeted NE IP 8.5 3 11 1142 93 12 106
EGFR-targeted NE IP 7.7 3 16 894 80 10 130
Non-targeted NE IV 8.7 0.08 32 1185 94 12 99
EGFR-targeted NE IV 5.9 0.5 27 696 81 8 131