. Author manuscript; available in PMC: 2017 Jun 1.

Published in final edited form as: Am J Clin Oncol. 2016 Jun;39(3):248–254. doi: 10.1097/COC.0000000000000046

Table 3.

Maximum post-baseline values after initiation of treatment.

		Maximum post-baseline values				Differences, Maximum – Baseline
Protein Label	Attained pCR?	Median¹	Lower Quartile¹	Upper Quartile¹	P²	Median¹	Lower Quartile¹	Upper Quartile¹	P²
ANG-1	no	43,700	35,400	50,100	1.00	5,490	-930	13,900	0.21
ANG-1	yes	42,200	38,200	46,300	1.00	11,100	4,890	19,800	0.21
ANG-2	no	7,790	5,450	10,800	0.59	1,000	-21.6	3,540	0.75
ANG-2	yes	8,340	6,170	11,300	0.59	2,430	-329.0	3,640	0.75
bFGF	no	75.7	38.7	83.6	0.037	9.4	0.0	42.1	0.43
bFGF	yes	105.0	75.3	156.0	0.037	5.9	-15.1	35.1	0.43
IL-1a	no	23.7	14.1	31.7	0.25	6.5	1.4	15.2	1.00
IL-1a	yes	28.1	18.9	48.5	0.25	7.9	-0.0	14.1	1.00
MMP-9	no	6,660	5,760	7,580	0.11	2,050	308	5,080	0.91
MMP-9	yes	7,460	6,850	8,280	0.11	1,980	247	4,300	0.91
PDGF-BB	no	19,400	16,300	23,400	0.64	1,540	-345	2,840	0.89
PDGF-BB	yes	19,900	16,900	24,200	0.64	1,430	-2,290	3,250	0.89
PECAM-1	no	1,950	1,640	2,840	0.97	623	-16.8	936	0.67
PECAM-1	yes	2,010	1,530	3,450	0.97	401	-317	1,130	0.67
Tie-2	no	517	431	943	0.14	198	71.3	475	0.37
Tie-2	yes	838	514	1150	0.14	114	50.9	294	0.37
VEGF	no	324	272	381	0.31	-875	-2,000	-370	0.28
VEGF	yes	362	303	404	0.31	-1,330	-4,140	-563	0.28
VEGF R2	no	5,790	5,010	6,580	0.61	1,520	123	2,840	0.26
VEGF R2	yes	5,420	4,790	6,230	0.61	532	290	1,570	0.26

Medians and quartiles are in units of pg/mL

P values are from 2-sided Wilcoxon rank-sum tests.