Table 4.
logistic-regression analysis of baseline serum proteins in the presence of ER/PR status.
| Serum Protein | Adjusted OR1 | 95% Confidence Interval | P | ER/PR status | Adjusted OR2 | 95% Confidence Interval | P |
|---|---|---|---|---|---|---|---|
| ANG-1 | 0.85 | 0.35–2.07 | 0.72 | –/– | 5.02 | 1.07–23.7 | 0.041 |
| ANG-2 | 1.11 | 0.52–2.35 | 0.79 | –/– | 5.26 | 1.14–24.2 | 0.033 |
| bFGF | 1.22 | 0.73–2.04 | 0.46 | –/– | 4.62 | 0.97–22.1 | 0.055 |
| IL-1a | 3.05 | 0.99–9.43 | 0.053 | –/– | 9.32 | 1.53–56.9 | 0.016 |
| MMP-9 | 1.07 | 0.26–4.44 | 0.93 | –/– | 5.24 | 1.10–25.0 | 0.038 |
| PDGF-BB | 1.16 | 0.48–2.79 | 0.74 | –/– | 5.64 | 1.17–27.1 | 0.031 |
| PECAM-1 | 1.29 | 0.46–3.59 | 0.63 | –/– | 4.98 | 1.06–23.4 | 0.042 |
| Tie-2 | 3.70 | 1.22–11.3 | 0.021 | –/– | 3.92 | 0.69–22.4 | 0.124 |
| VEGF | 1.72 | 0.92–3.23 | 0.091 | –/– | 7.61 | 1.36–42.6 | 0.021 |
| VEGF-R2 | 1.56 | 0.56–4.35 | 0.40 | –/– | 5.05 | 1.08–23.6 | 0.040 |
1
Adjusted odds ratio favoring pCR with a one-unit increase in baseline level of the indicated serum protein, adjusting for the presence of ER/PR status in the logistic-regression model. Protein concentrations were normalized so that one unit of increase in baseline level is equal to the protein's interquartile range (IQR) at baseline.
2
Adjusted odds ratio favoring pCR in subjects with ER/PR=“–/–” compared to subjects with at least one “+”, adjusting for the presence of baseline serum-protein levels in the logistic-regression model.