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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Cancer Res. 2015 May 6;75(13):2716–2728. doi: 10.1158/0008-5472.CAN-14-3655

Figure 6.

Figure 6

2′-HCA inhibits HEL and A431 tumor growth in a mouse xenograft model. Mice implanted with (A) HEL or (B) A431 cells were administered 2′-HCA or the vehicle control. Tumors were removed at 5 weeks after implantation of cells. HEL and A431 tumor volume (A, B) and tumor mass (C, D) were determined as described in Materials and Methods (n = 16). Representative images and quantification of PCNA (green) and cleaved caspase 3 (red) staining of (E) HEL and (F) A431 tumors (n = 12). Scale bars = 100 μM. Data are represented as mean values ± S.E. Immunoblotting and quantification of phosphorylated and basal levels of Bad in (G) HEL and (H) A431 tumor lysates (n = 6). Data are represented as mean values ± S.E. The asterisks (*, **) indicate a significant (p < 0.05, p < 0.01) difference between the vehicle-treated and 2′-HCA-treated groups.